उत्पाद विवरण
Mesalazine also known as mesalamine or 5aminosalicylic acid is a medication primarily used to treat inflammatory bowel diseases including ulcerative colitis and Crohns disease It works by reducing inflammation in the colon
Specifications of Mesalazine
1 Formulations
Oral tablets
Oral capsules
Rectal suppositories
Rectal enemas
2 Dosage Forms and Strengths
Oral TabletsCapsules Typically available in strengths such as 400 mg 800 mg and 12 g
Rectal Suppositories Usually available in strengths such as 500 mg and 1 g
Rectal Enemas Generally available in 4 g60 mL formulations
3 Mechanism of Action
Mesalazine is an antiinflammatory drug that targets the lining of the gut to reduce inflammation It is thought to inhibit the production of certain chemicals in the body prostaglandins and leukotrienes that cause inflammation
4 Indications
Treatment of mild to moderate ulcerative colitis
Maintenance of remission in ulcerative colitis
Sometimes used in Crohns disease
5 Pharmacokinetics
Absorption Oral forms are designed to release mesalazine in the colon The extent of absorption varies with the formulation
Metabolism Mesalazine is metabolized in the liver and intestines to Nacetyl5aminosalicylic acid
Excretion Primarily excreted in the urine and feces
6 Side Effects
Common Nausea headache abdominal pain diarrhea and flatulence
Serious Kidney problems pancreatitis pericarditis and worsening of ulcerative colitis symptoms
7 Contraindications
Hypersensitivity to mesalazine or salicylates
Severe renal or hepatic impairment
8 Drug Interactions
Mesalazine may interact with other nephrotoxic drugs increasing the risk of kidney damage
Possible interaction with azathioprine or 6mercaptopurine potentially increasing the risk of blood disorders
9 Monitoring
Regular monitoring of renal function is recommended especially in patients with known kidney issues
Monitoring for blood disorders in patients concurrently taking azathioprine or 6mercaptopurine
Important Considerations
Administration Follow the specific instructions provided with the formulation especially for rectal forms
Storage Store in a cool dry place away from direct sunlight
Patient Education Inform patients about the importance of adherence to the prescribed regimen and the need to report any unusual symptoms to their healthcare provider promptly
If you need more detailed information about a specific aspect of mesalazine or have any other questions feel free to ask
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