Mesalazine IP/BP/USP

Product Description

Mesalazine also known as mesalamine or 5aminosalicylic acid is a medication primarily used to treat inflammatory bowel diseases including ulcerative colitis and Crohns disease It works by reducing inflammation in the colon

 Specifications of Mesalazine

1 Formulations

    Oral tablets

    Oral capsules

    Rectal suppositories

    Rectal enemas

2 Dosage Forms and Strengths

    Oral TabletsCapsules Typically available in strengths such as 400 mg 800 mg and 12 g

    Rectal Suppositories Usually available in strengths such as 500 mg and 1 g

    Rectal Enemas Generally available in 4 g60 mL formulations

3 Mechanism of Action

    Mesalazine is an antiinflammatory drug that targets the lining of the gut to reduce inflammation It is thought to inhibit the production of certain chemicals in the body prostaglandins and leukotrienes that cause inflammation

4 Indications

    Treatment of mild to moderate ulcerative colitis

    Maintenance of remission in ulcerative colitis

    Sometimes used in Crohns disease

5 Pharmacokinetics

    Absorption Oral forms are designed to release mesalazine in the colon The extent of absorption varies with the formulation

    Metabolism Mesalazine is metabolized in the liver and intestines to Nacetyl5aminosalicylic acid

    Excretion Primarily excreted in the urine and feces

6 Side Effects

    Common Nausea headache abdominal pain diarrhea and flatulence

    Serious Kidney problems pancreatitis pericarditis and worsening of ulcerative colitis symptoms

7 Contraindications

    Hypersensitivity to mesalazine or salicylates

    Severe renal or hepatic impairment

8 Drug Interactions

    Mesalazine may interact with other nephrotoxic drugs increasing the risk of kidney damage

    Possible interaction with azathioprine or 6mercaptopurine potentially increasing the risk of blood disorders

9 Monitoring

    Regular monitoring of renal function is recommended especially in patients with known kidney issues

    Monitoring for blood disorders in patients concurrently taking azathioprine or 6mercaptopurine

 Important Considerations

 Administration Follow the specific instructions provided with the formulation especially for rectal forms

 Storage Store in a cool dry place away from direct sunlight

 Patient Education Inform patients about the importance of adherence to the prescribed regimen and the need to report any unusual symptoms to their healthcare provider promptly

If you need more detailed information about a specific aspect of mesalazine or have any other questions feel free to ask