उत्पाद विवरण
Lidocaine IP Indian Pharmacopoeia Full Description
Chemical Name
2DiethylaminoN26dimethylphenylacetamide
Molecular Formula
C14H22N2O
Molecular Weight
23434 gmol
Appearance
Lidocaine appears as a white or almost white crystalline powder
Assay
Lidocaine must contain not less than 990 and not more than 1010 of C14H22N2O calculated on the anhydrous basis This ensures the purity and efficacy of the drug
Identification
Lidocaine is identified using the following methods
Infrared Absorption Spectrophotometry The infrared absorption spectrum of the sample should be concordant with the reference spectrum
Chromatographic Methods The retention time of the major peak in the chromatogram of the test solution should correspond to that in the chromatogram of the standard solution
Solubility
Soluble in water
Freely soluble in ethanol 95 and in chloroform
Practically insoluble in ether
pH
The pH of a 1 aqueous solution of lidocaine should be between 45 and 65
Loss on Drying
Lidocaine should have a loss on drying of not more than 05 indicating the amount of moisture content in the substance
Related Substances
Impurities Specific limits are set for individual and total impurities
Heavy Metals Should not exceed specified limits
Melting Point
The melting point of lidocaine should be between 66C and 70C
Specific Optical Rotation
The specific optical rotation of lidocaine should be between 010 and 010
Storage
Store lidocaine in a wellclosed container protected from light This helps in maintaining the stability and potency of the drug
Usage
Lidocaine is widely used as a local anesthetic and antiarrhythmic agent It works by blocking nerve signals in the body providing pain relief and stabilizing the hearts electrical activity in arrhythmias
This comprehensive description ensures that lidocaine meets the stringent quality standards required by the Indian Pharmacopoeia ensuring its safety and efficacy for medical use
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