Lidocaine IP

Product Description

 Lidocaine IP Indian Pharmacopoeia Full Description

Chemical Name 

2DiethylaminoN26dimethylphenylacetamide

Molecular Formula 

C14H22N2O

Molecular Weight 

23434 gmol

Appearance

Lidocaine appears as a white or almost white crystalline powder

Assay

Lidocaine must contain not less than 990 and not more than 1010 of C14H22N2O calculated on the anhydrous basis This ensures the purity and efficacy of the drug

Identification

Lidocaine is identified using the following methods

 Infrared Absorption Spectrophotometry The infrared absorption spectrum of the sample should be concordant with the reference spectrum

 Chromatographic Methods The retention time of the major peak in the chromatogram of the test solution should correspond to that in the chromatogram of the standard solution

Solubility

 Soluble in water

 Freely soluble in ethanol 95 and in chloroform

 Practically insoluble in ether

pH

The pH of a 1 aqueous solution of lidocaine should be between 45 and 65

Loss on Drying

Lidocaine should have a loss on drying of not more than 05 indicating the amount of moisture content in the substance

Related Substances

 Impurities Specific limits are set for individual and total impurities

 Heavy Metals Should not exceed specified limits

Melting Point

The melting point of lidocaine should be between 66C and 70C

Specific Optical Rotation

The specific optical rotation of lidocaine should be between 010 and 010

Storage

Store lidocaine in a wellclosed container protected from light This helps in maintaining the stability and potency of the drug

Usage

Lidocaine is widely used as a local anesthetic and antiarrhythmic agent It works by blocking nerve signals in the body providing pain relief and stabilizing the hearts electrical activity in arrhythmias

This comprehensive description ensures that lidocaine meets the stringent quality standards required by the Indian Pharmacopoeia ensuring its safety and efficacy for medical use